Abstract
This study presents a DEP-based lab-on-a-chip (LOC) system for label-free detection of multidrug resistant (MDR) K562 leukemia cells in a cell mixture, consisting of red blood cells (RBCs) and MDR-K562 cells, for the first time in the literature. The system consists of 2 consecutive DEP units, one for the depletion of RBCs and the other for capturing of MDR-K562 cells. RBCs are depleted by 60% in the first unit. In the second unit, MDR-K562 cell detection is performed with 100% selectivity at a flow rate of 10 μl/min and at 20 Vpp in a cell mixture, containing less than 25% MDR-K562 cells.
Cite
CITATION STYLE
Yalçın, Y. D., Özkayar, G., Özgür, E., Gündüz, U., & Külah, H. (2016). A DEP-based lab-on-a-chip system for the detection of multidrug resistance in K562 leukemia cells. In 2016 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016 (pp. 316–319). Transducer Research Foundation. https://doi.org/10.31438/trf.hh2016.86
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