The synthesis and transformations of fused bicyclo[2.2.2]octenes

Abstract

The synthesis and transformations of bicyclo[2.2.2]octenes with the emphasis on substituted bicyclo[2.2.2]oct-7-ene-2,3,5,6-tetracarboxylic acid derivatives bearing a substituted amino group at the bridgehead carbon atom are presented. The main topic of this review is the Diels-Alder reaction, as the most important tool for preparing compounds of this type. The transformations of bicyclo[2.2.2]oct-7-ene-2,3,5,6-tetracarboxylic acid dianhydride derivatives with nitrogen-containing nucleophiles are discussed as well as the derivatisation of the olefinic C=C double bond. ©ARKAT USA, Inc.