Antiobesity activity of aqueous and ethanol extracts of Aegle marmelos leaves in high fat diet induced obese rats

Abstract

Obesity is a chronic disorder of global prevalence and associated with morbidity and mortality. The presents work evaluates the effect of ethanol (AmEe) and aqueous (AmAe) extracts of Aegle marmelos leaves in high fat diet (HFD) induced obese rats. Male Wistar rats weighing 150-200 g were divided into different groups i.e. Normal control, HFD control, Orlistat (lipase inhibitor), AmEe and AmAe at doses of 200, 400, 250 and 500 mg/kg. Treatment was started after 6 weeks upto 12 weeks along with HFD (except normal control). Oxidative stress was measured by measuring MDA, SOD and GSH level. AmEe and AmAe at 200, 400, 250 and 500 mg/kg/orally significantly attenuated oxidative stress as well as morphological parameters i.e. % body weight gain, BMI, WHR, obesity index, adiposity index respectively as compare to HFD control group. Similarly, serum glucose, triglyceride and total cholesterol were found to be attenuated as compare to HFD control group. Thus AmEe and AmAe exhibited antiobesity activity may due to decrease fat pad mass, by reduced adipocyte differentiation or by decreasing adipocyte hypertrophy in high fat diet induced obese rats.