Introduction: Overview of the pathophysiological implications of store-operated calcium entry in mammalian cells

Abstract

Since store-operated Ca2+ entry (SOCE) was proposed by Putney three decades ago (Putney. Cell Calcium 7:1–12, 1986), its functional role and involvement in the pathophysiology of a number of disorders has been investigated. The role of SOCE in cell physiology has been discussed in the previous chapters, and the following part is devoted to the current knowledge concerning the mechanisms underlying the development of certain diseases that involve SOCE abnormalities.