A 2-way mirRor of red blood cells and leukemia

Abstract

In this issue of Blood, the articles by Shaham et al1 and Wang et al2 are the first to identify microRNA 486 (miR-486) as a requisite oncomiR and credible therapeutic target in myeloid leukemia of Down syndrome (ML-DS) and chronic myeloid leukemia (CML) by showing that these 2 leukemias co-opt miR-486 functions in normal erythroid progenitor progrowth and survival activity.