Two alternatives for the synthesis of pyrrolo[1,2-a]quinoxaline derivatives

Abstract

The 4,5-dihydropyrrolo[1,2-a]quinoxaline system was prepared through two different reaction sequences. The first method is based on the intramolecular reductive amination of the corresponding nitrophenylpyrrole-carbaldehyde intermediate, whereas an alternative synthesis involves as key step, the intramolecular substitution of an aromatic fluoride by a secondary amine. ©ARKAT USA, Inc.