A Critique on Baroreceptor and their Effective Reflex Action on Compartmental Cardiovascular Modeling in Regulating Hemodynamic Parameters

Abstract

Baroreceptor is the feedback unit present in the living beings which acts as a sensor that is located in the walls of blood vessels. This sensor senses the deformation in the blood vessels which causes change in arterial blood pressure and regulates it via Central Nervous System (CNS) and the information are autonomic reflexes that has a great influence on circulatory system elements such as peripheral systemic resistance (Rpsym), contractility of the ventricles (Emax), unstressed volume of the ventricles (Vus_ven) and heart rate (HR). The dynamic behaviour of the baroreceptor is modeled and substantiated by applying the negative feedback mechanism. A detailed modeling and simulation study is presented considering various testing conditions in regulating the circulatory system elements which oversees the Mean Arterial Pressure (MAP) in cardiovascular system. The Total Artificial Cardiovascular model (TAH-CVS) is also developed using pressure, volume and flow related differential equations. Based on the testing conducted under various conditions, the feedback-mechanism of the baroreceptor model is combined with the continuous TAH-CVS closed loop model to validate the effectiveness of the baroreceptor model. The simulation results of TAH-CVS model at initial conditions are compared with the TAH-CVS model with baroreceptor.