Improvement of the kirromycin fermentation by resin addition

Abstract

The kirromycin yield of Actinoplanes sp A8924 was improved from 30-50 mg L-1 to 350 mg L-1 by mutant selection and medium optimization. The incorporation of polystyrenic resins into the fermentations promoted a further fourfold enhancement of kirromycin productivity to 1500 mg L-1. The positive effect of resin addition appears to be due to removal of kirromycin from the fermentation broth because kirromycin's minimal inhibitory concentration against the producing strain remained at ca 350 mg L-1.