Levels of C‐reactive protein in pregnant women who subsequently develop pre‐eclampsia

Abstract

Objective To investigate whether a maternal inflammatory response precedes the development of pre‐eclampsia. Design Cross‐sectional study. Setting Antenatal clinic in an inner city teaching hospital. Population Two groups of women were examined at 23–25 weeks of gestation. The first group (45 women) had normal uterine artery Doppler waveforms and subsequently had a normal pregnancy outcome. The second group (45 women) had Doppler evidence of impaired placental perfusion and 21 (47%) of them had normal outcome, 14 (31%) developed intrauterine growth restriction and 10 (22%) developed pre‐eclampsia, with or without intrauterine growth restriction. Methods C‐reactive protein, an acute‐phase reactant, was measured in maternal serum using a highly sensitive method with a detection limit of 0.05mg/L. Main Outcome Measures Development of pre‐eclampsia, as defined by the International Society for the Study of Hypertension in Pregnancy. Intrauterine growth restriction was defined as birthweight <5th centile for gestation and sex of the neonate. Results The serum C‐reactive protein concentration in women who subsequently developed pre‐eclampsia (median 1.56, range 0.55–3.12mg/L) or delivered a baby with birthweight <5th centile (median 0.74, range 0.64–1.58mg/L) was not significantly different from that in women with uncomplicated pregnancies (median 1.28, range 0.75–2.08mg/L; P = 0.95 and P = 0.62 , respectively). Conclusion These findings suggest that the onset of clinical signs of pre‐eclampsia may not be preceded by a maternal inflammatory response, as assessed by measurement of C‐reactive protein.