Highly selective synthesis of β-amino carbonyl compounds over ZSM-5-SO3h under solvent-free conditions

Abstract

ZSM-5-SO3H efficiently catalyzed the one-pot three-component Mannich reaction of aldehydes, anilines, and ketones. β-Aminocarbonyl compounds were obtained in reasonable yields and excellent stereoselectivities when the reaction was carried out at room temperature under solvent-free conditions. Simple experimental conditions and product isolation procedure makes this protocol potential for the development of clean and environment-friendly strategy for the synthesis of β-amino-ketones. The catalyst was recovered and reused for subsequent runs.