Interaction of tumor cells with the microenvironment

264Citations
Citations of this article
358Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Recent advances in tumor biology have revealed that a detailed analysis of the complex interactions of tumor cells with their adjacent microenvironment (tumor stroma) is mandatory in order to understand the various mechanisms involved in tumor growth and the development of metastasis. The mutual interactions between tumor cells and cellular and non-cellular components (extracellular matrix = ECM) of the tumor microenvironment will eventually lead to a loss of tissue homeostasis and promote tumor development and progression. Thus, interactions of genetically altered tumor cells and the ECM on the one hand and reactive non-neoplastic cells on the other hand essentially control most aspects of tumorigenesis such as epithelial-mesenchymal-transition (EMT), migration, invasion (i.e. migration through connective tissue), metastasis formation, neovascularisation, apoptosis and chemotherapeutic drug resistance. In this mini-review we will focus on these issues that were recently raised by two review articles in CCS. © 2011 Ungefroren et al; licensee BioMed Central Ltd.

Cite

CITATION STYLE

APA

Ungefroren, H., Sebens, S., Seidl, D., Lehnert, H., & Hass, R. (2011). Interaction of tumor cells with the microenvironment. Cell Communication and Signaling. https://doi.org/10.1186/1478-811X-9-18

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free