Clean synthesis of N-pyrrolyl azoles by metal-free oxidative cross-coupling using recyclable hypervalent iodine reagent

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Abstract

The facile and clean oxidative coupling reaction of pyrroles with azoles has been achieved using the recyclable hypervalent iodine(III) reagents having adamantane structures. These iodine(III) reagents could be recovered from the reaction mixtures by a simple solid-liquid separation, i.e., filtration, for reuse.

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Morimoto, K., Ogawa, R., Koseki, D., Takahashi, Y., Dohi, T., & Kita, Y. (2015). Clean synthesis of N-pyrrolyl azoles by metal-free oxidative cross-coupling using recyclable hypervalent iodine reagent. Chemical and Pharmaceutical Bulletin, 63(10), 819–824. https://doi.org/10.1248/cpb.c15-00469

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