Antihyperglycemic Effect of Methanolic Extract of Aphanamixis polystachya Leaves on Streptozotocin-Induced Diabetic Rats

Abstract

This study aimed to investigate the antidiabetic effect of methanolic extract of Aphanamixis polystachya leaves in streptozotocin (STZ) induced diabetic rats. Wistar rats in each were divided into six groups and these animals were used for the study. In our study methanolic extract of Aphanamixis polystachya leaves was screened for antidiabetic activity in streptozotocin (STZ)-induced diabetic rats. The anti-diabetic activity was assessed using blood glucose level, body weight and various biochemical parameters like serum total cholesterol level (TC), triglyceride (TG) level, high-density lipoproteins (HDL), total protein (TP), serum alanine transaminase (SGPT) and aspartate aminotransferase (SGOT), respectively. The methanolic extract of Aphanamixis polystachya leaves exhibited an antidiabetic effect by significantly decreased the level of blood glucose, body weight, TC, TG, TP and increase HDL. The results of the study demonstrated that the treatment with methanolic extract of Aphanamixis polystachya leaves significantly (P<0.05) and dose-dependently prevented STZ-induced diabetic rats. The antioxidant property of plant phenolic and flavonoid contents present in methanolic extract of Aphanamixis polystachya leaves might be responsible for the antidiabetic activity. Keywords: Aphanamixis polystachya leaves; diabetes; streptozotocin