An apparent, locally acquired case of rickettsialpox (Rickettsia akari) in ontario, canada

Abstract

Rickettsialpox, caused by Rickettsia akari, is a spotted fever group rickettsiae transmitted to humans through the bite of the house mouse mite (Liponyssoides sanguineus). Worldwide, rickettsialpox is most commonly associated with exposure to rodents in urban environments. Here, we present the case of a 47-year-old woman from Brantford, Ontario, with fever, eschar on the right leg, expanding erythema, and right groin lymphadenopathy. Early in infection, R. akari serology was negative (IgG <1:64), but convalescent titre increased to 1:1,024. The patient did not travel outside of Ontario in the previous year. She denied any rodent or arthropod exposures in her home, but recently visited a friend’s home infested with bats and mice. The patient was afebrile after treatment with doxycycline, with resolution of most clinical and laboratory findings in 5 days. This is the first rickettsialpox case reported in Canada and highlights the importance of obtaining convalescent serology to assist in the diagnosis of rickettsial infection.