Differential diagnosis for sinonasal tumors

Abstract

Aim and objective: To describe small round blue cell tumors (SRBCT) of the sinonasal cavity which are tumors that are likely to be misdiagnosed due to their presenting features that often mimic each other. Background: Small round blue cell tumors clinically tend to cause symptoms of nasal obstruction and epistaxis. They have overlapping histologic and immunophenotypic findings; hence, a proper workup is required to reach the proper diagnosis and for further management of each case. Case description: We present two cases of SRBCT, where the patients presented with a 1-month history of nasal obstruction and episodes of epistaxis, along with ophthalmologic symptoms in one of the cases. The patients were diagnosed with histopathology and immunohistochemistry and responded well to surgical treatment and chemoradiotherapy. Conclusion: Sinonasal masses with erosive potential can have a wide differential diagnosis. Small round blue cell tumors respond well to surgical debridement and combined chemoradiotherapy, which can effectively prevent tumor recurrence in many cases. Clinical significance: Early diagnosis and proper management of the tumors effectively improve the treatment outcome and lead to lowering of mortality and morbidity for the patient.