Synthesis and Antiinflammatory Activity of 3-Aryl-5-Isopropyl-1,2,4-Oxadiazoles

Abstract

Seven 4,5-dihydro-1,2,4-oxadiazoles 3a-g have been synthesized from arylamidoximes 1a-g and isobutyraldehyde 2 in the presence of an acid catalyst (IRP-64). Oxidation of 3a-g either with MnO2 or with nitric acid provided 4a-g. Compounds 3b,c,f,g and 4b,c,e-g have not been reported in the literature. All seven oxadiazoles 4a-g showed antiinflammatory activity.