Prenatal diagnosis of congenital human cytomegalovirus infection in amniotic fluid by nucleic acid sequence-based amplification assay

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Abstract

Nucleic acid sequence-based amplification assays for detection of human cytomegalovirus (HCMV) immediate-early and pp67 mRNA in 65 amniotic fluid samples tested for prenatal diagnosis of congenital HCMV infection showed sensitivity, specificity, and negative and positive predictive values >90%.

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Revello, M. G., Lilleri, D., Zavattoni, M., Furione, M., Middeldorp, J., & Gerna, G. (2003). Prenatal diagnosis of congenital human cytomegalovirus infection in amniotic fluid by nucleic acid sequence-based amplification assay. Journal of Clinical Microbiology, 41(4), 1772–1774. https://doi.org/10.1128/JCM.41.4.1772-1774.2003

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