Association between scalp and intracerebral electroencephalographic seizure-onset patterns: A study in different lesional pathological substrates

Abstract

Objective: Our purpose was to determine the correlation between scalp electroencephalography (EEG) and intracerebral EEG (iEEG) seizure-onset patterns in patients with focal lesional epilepsy to determine whether scalp seizure-onset patterns can be specific to intracerebral seizure-onset patterns and to lesion type. Methods: We retrospectively analyzed 61 patients with focal epilepsy and a structural magnetic resonance imaging (MRI)-visible lesion, who first underwent extensive scalp recordings and then iEEG studies (stereo-EEG) for presurgical evaluation, and who showed an iEEG seizure onset in the lesional/perilesional area. Five seizure-onset patterns were recognized on scalp EEG, and 7 on iEEG, and in each patient, only the predominant scalp and iEEG seizure-onset patterns were compared. Because scalp and iEEG recordings were acquired at different times, we followed strict criteria based on semiology and topography to match scalp with intracerebral seizures. Results: Seventy-one pairs of seizure-onset patterns matched between scalp and iEEG were identified. Each scalp pattern did not correspond to a single intracerebral pattern, but there were significant associations: (1) paroxysmal fast activity (≥13 Hz) at scalp onset was associated with low-voltage fast activity at iEEG onset (P <13 Hz) at scalp onset was associated with low-frequency high-amplitude periodic spikes at iEEG onset (P =.0014), with medial temporal atrophy/sclerosis (P