Cytocompatible and antibacterial efficacy of surface designed Ti40Cu40Zr11Fe3Sn3Ag3 amorphous alloy for potential biomedical applications

Abstract

This study explores the feasibility of utilizing chemically treated Ti40Cu40Zr11Fe3Sn3Ag3 at% amorphous alloy as a potential implant material. This work involves synthesis of nano-structured surfaces using chemical pseudo-dealloying by employing an ammonia-based solution (NH4OH and H2O2). Two distinct surfaces were developed by modifying solution concentration and in vitro cytocompatibility and antibacterial response of the treated ribbon samples were assessed. The findings reveal that the modified Ti-based amorphous alloy is cytocompatible with Saos-2 and HOb cells and exhibits antibacterial activity against the clinically relevant gram-negative pathogen Pseudomonas aeruginosa. Moreover, the modified surfaces can induce the release of reactive oxygen species, such as hydroxyl radicals, in a cell-free medium simulating an inflammatory system, suggesting a potential antibacterial response.