Cyclosporine Blocks Incorporation of HIV-1 Envelope Glycoprotein into Virions

  • Sokolskaja E
  • Olivari S
  • Zufferey M
  • et al.
14Citations
Citations of this article
44Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Cyclosporine (CsA) decreases HIV-1 infectivity by blocking HIV-1 capsid (CA) interaction with target cell cyclophilin A (CypA). Yet, HIV-1 virions produced in the presence of CsA also exhibit decreased infectivity that was previously shown to be independent of the well-characterized HIV-1 CA-CypA interaction. Here, we demonstrate that CsA decreases gp120 and gp41 incorporation into HIV-1 virions and that the fusion of these virions with susceptible target cells is impaired. This effect was not observed with HIV-1 virions pseudotyped with the vesicular stomatitis virus glycoprotein or with the amphotropic envelope protein of murine leukemia virus. It was independent of calcineurin signaling, the endoplasmic reticulum luminal protein cyclophilin B, and the long cytoplasmic tail of gp41. Thus, cyclosporine blocks HIV-1 infectivity via two independent mechanisms, the first involving HIV-1 CA in target cells and the second involving HIV-1 Env in producer cells.

Cite

CITATION STYLE

APA

Sokolskaja, E., Olivari, S., Zufferey, M., Strambio-De-Castillia, C., Pizzato, M., & Luban, J. (2010). Cyclosporine Blocks Incorporation of HIV-1 Envelope Glycoprotein into Virions. Journal of Virology, 84(9), 4851–4855. https://doi.org/10.1128/jvi.01699-09

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free