Design, Synthesis, Fungicidal Activity and Docking Study of Acyl Urea Derivatives Containing Pyrazole Moiety

Abstract

A series of novel acyl urea derivatives containing pyrazole moiety were synthesized from ethyl acetoacetate, triethyl orthoformate, methylhydrazine by multi-step reactions. Their structures were characterized by 1H NMR and HRMS spectra. The target compounds were evaluated for their fungicidal activity. The results indicated that some of the title compounds displayed certain fungicidal activities against Cercospora arachidicola, Sclerotinia sclerotiorum, Rhizoctonia solani and Physalopora piricola. The docking results indicated the hydrogen bond formed between the amide group and Ser 39 residue.