Haemolytic uraemic syndrome and Shiga toxin-producing Escherichia coli infection in children in France

79Citations
Citations of this article
17Readers
Mendeley users who have this article in their library.

Abstract

We conducted a study to determine the incidence of haemolytic uraemic syndrome (HUS) in children in France and to assess the role of Shiga-toxin-producing Escherichia coli (STEC) infection in the aetiology of HUS. In collaboration with the Societe de Nephrologie Pediatrique we undertook a retrospective review of all cases of HUS hospitalized from January 1993 to March 1995 and a 1-year prospective study (April 1995-March 1996) of epidemiological and microbiological features of cases of HUS. The polymerase chain reaction (PCR) procedure was used to detect stx, eae, e-hlyA genes directly from case stool samples. Serum samples from cases were examined for antibodies to lipopolysaccharide (LPS) of 26 major STEC serogroups. Two hundred and eighty-six cases were reported. The average incidence per year was 0.7/105 children < 15 years and 1.8/105 children < 5 years. During the prospective study, 122/130 cases were examined for evidence of STEC infection using PCR and/or serological assays and 105 (86%) had evidence of STEC infection. Serum antibodies to E. coli O157 LPS were detected in 79 (67%) cases tested. In conclusion, this study showed that STEC infection is an important cause of HUS in children in France, with a high proportion related to the O157 serogroup.

Cite

CITATION STYLE

APA

Decludt, B., Bouvet, P., Mariani-Kurkdjian, P., Grimont, F., Grimont, P. A. D., Hubert, B., … Nivet, H. (2000). Haemolytic uraemic syndrome and Shiga toxin-producing Escherichia coli infection in children in France. Epidemiology and Infection, 124(2), 215–220. https://doi.org/10.1017/S0950268899003623

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free