Investigation of the effect of tetrahydroaminoacridine on turnover kinetics of camel (Camelus dromedarius) retina acetylcholinesterase

Abstract

The effect of tetrahydroaminoacridine (THA) on turnover kinetics of camel retina acetylcholinesterase has been investigated. The turnover number (K(cat)) and specificity constant (K(sp)) were 62.1 min-1 and 9.92 x 105 (M. min)-1 in the control system while the values for both parameters were lowered by 25-68% and 48-87% in the THA (0.05-0.4 μM) treated systems respectively. Therefore, THA's effect on turnover number must be considered at the time of therapy to the Alzheimer's disease patients.