Hexahydro-Pyrrolo[1,2,5:3,4,5]Thiazolo[3,4-c]Oxazol-1-ones: New Chiral Tricyclic L-Cysteine and D-Penicillamine Derivatives

Teresa M.V.D. Pinho e Melo; Susana M.M. Lopes; Antonio M. d'A. Rocha Gonsalves; Agnieszka Kaczor; Rui Fausto; Jose Paixao; Ana Matos Beja; Manuela Ramos Silva

Journal ArticleOPEN ACCESS

Hexahydro-Pyrrolo[1,2,5:3,4,5]Thiazolo[3,4-c]Oxazol-1-ones: New Chiral Tricyclic L-Cysteine and D-Penicillamine Derivatives

Pinho e Melo T
Lopes S
Rocha Gonsalves A
et al.

Letters in Organic Chemistry (2006) 3(11) 820-826

DOI: 10.2174/157017806779116996

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Abstract

A simple and efficient approach to the synthesis of the new chiral hexahydropyrrolo [1′,2′,5′:3,4,5]thiazolo[3,4-c] oxazol-1-one ring system is reported. Infrared spectroscopy, quantum-chemical calculations and X-ray analysis allowed the stereochemistry assignment of (2aS,4aR,6aR)-2a,3,4,4a,6, 6a-hexahydropyrrolo-[1′,2′,5′:3,4,5]thiazolo [3,4-c]oxazol-1-one. © 2006 Bentham Science Publishers Ltd.

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Pinho e Melo, T. M. V. D., Lopes, S. M. M., Rocha Gonsalves, A. M. d’A., Kaczor, A., Fausto, R., Paixao, J., … Ramos Silva, M. (2006). Hexahydro-Pyrrolo[1,2,5:3,4,5]Thiazolo[3,4-c]Oxazol-1-ones: New Chiral Tricyclic L-Cysteine and D-Penicillamine Derivatives. Letters in Organic Chemistry, 3(11), 820–826. https://doi.org/10.2174/157017806779116996

Hexahydro-Pyrrolo[1,2,5:3,4,5]Thiazolo[3,4-c]Oxazol-1-ones: New Chiral Tricyclic L-Cysteine and D-Penicillamine Derivatives

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