Recent developments in the synthesis of pyrrolidine-containing iminosugars

Abstract

As noted inhibitors of glycosidases, iminosugars have enormous therapeutic potential in the treatment: of a number of diseases such as cancer, diabetes, and lysosomal storage disorders. Accordingly, much effort has been expended over the past decades in developing novel and efficient methodologies for the synthesis of iminosugars. This microreview highlights recent: (post 2005) developments in the synthesis of pyrrolidine-containing iminosugars and includes discussions of methodologies such as ring-closing metathesis, aldol and pericyclic reactions, and protecting-group free strategies. © 2010 Wiley-VCH Verlag GmbH &. Co. KGaA.