Beta thalassemia and role of herbals and hematopoietic stem cells in its remedy

Abstract

Genetic disorders caused by mutations in the β-globin gene are widely known as the human β-hemoglobinopathies, in which there is β-thalassemia. In recent years, effort has been made to identify the natural inducers and drug treatments which can increase the synthesis of fetal hemoglobin and promote the expression of fetal γ-globin gene. This review aims to reveal the novel screening platforms for identifying potential herbal inducers with high efficiency and accuracy and to describe the hematopoietic stem cells remedies to provide perspectives in fetal hemoglobin reactivation for treating β-thalassemia.