Screening of peptides to find the ligands that bind to specific targets is an important step in drug discovery. These high-throughput screens require large number of structural variants of peptides to be synthesized and tested. This chapter describes the generation of arrays of peptides on Teflon-patterned sheets of paper. First, the protocol describes the patterning of paper with a Teflon solution to produce arrays with solvophobic barriers that are able to confine organic solvents. Next, we describe the parallel syntheses of 96 peptides on Teflon-patterned arrays using the SPOT synthesis method.
CITATION STYLE
Deiss, F., Yang, Y., & Derda, R. (2016). Parallel syntheses of peptides on teflon-patterned paper arrays (Syntarrays). In Methods in Molecular Biology (Vol. 1368, pp. 249–271). Humana Press Inc. https://doi.org/10.1007/978-1-4939-3136-1_18
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