Regioselective synthesis of fluorohydrines via SN2-type ring-opening of epoxides with TBABF-KHF2

Abstract

We found that the ring-opening fluorination of terminal epoxides using TBABF-KHF2 proceeds with high selectivity through the SN2 mechanism. As TBABF-KHF2 is easily obtainable, is stable, and can be used in glassware, it can be a useful reagent for 1-fluoro-2-alkanol synthesis from the terminal epoxides.