Regulatory role of Peyer's patches for the inhibition of OVA-induced allergic diarrhea

37Citations
Citations of this article
38Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Intestinal allergic diseases are initiated by aberrant Th2-type immune responses, including elevation of IgE antibodies (Abs) and infiltration of eosinophils. However, little is known about the role of Peyer's patches (PP) in the control of allergic diseases. Using a mouse model for food allergy, we here show that mice lacking PP are more susceptible to disease development and show higher levels of antigen-specific IgE Abs than do PP-intact mice. In our study, we noted that high numbers of eosinophils infiltrated into the small intestine of PP-null mice. In contrast, the PP of intact mice contained regulatory CD4+CD25+ Foxp3+ T cells (Treg) that are known to produce high levels of IL-10, and inhibited the development of allergic diarrhea. PP-intact mice thus developed allergic diarrhea when treated with anti-CD25 or anti-IL-10 monoclonal antibody (mAb) in vivo. These studies demonstrate that PP, as the site where IL-10-producing Treg cells are created, mediate the mucosal regulatory network for the control of undesired allergic responses in the intestine. © 2007 Elsevier Inc. All rights reserved.

Author supplied keywords

Cite

CITATION STYLE

APA

Takayama, N., Igarashi, O., Kweon, M. N., & Kiyono, H. (2007). Regulatory role of Peyer’s patches for the inhibition of OVA-induced allergic diarrhea. Clinical Immunology, 123(2), 199–208. https://doi.org/10.1016/j.clim.2007.01.007

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free