Predictors of outcome in refractory generalized convulsive status epilepticus

Abstract

Objective: Refractory status epilepticus is a serious condition in which seizure continues despite use of two antiepileptic medications. Retrospective studies have shown that 29%-43% of SE patients progress into RSE despite treatment. Mortality following RSE is high. We aimed to evaluate the predictors of outcome in patients with RSE at a tertiary care center. Methods: Sixty-eight consecutive patients with RSE who presented to our hospital between February 2018 and January 2020 were evaluated for outcome. Result: In our study 28(41.2%), patients who failed to respond to first- and second-line antiepileptic drug responded to the third-line antiepileptic drug thus avoiding mechanical ventilation and intravenous anesthesia. Low GCS at admission (P