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Immunoinformatics as a tool for new antifungal vaccines

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Abstract

Immunoinformatics aids in screening for vaccine candidates, which can be experimentally tested for their efficacy. This chapter describes methods to use immunoinformatics to screen fungal vaccines candidates. Surface-localized molecules called adhesins could elicit immune response and serve as efficient vaccine candidates. The screening process is patterned on two steps, namely, a First Layer screen mostly used for value addition and prioritization based on characteristics of known antigens and a Second Layer highly focussed on core immunoinformatics analysis involving the binding and interactions of the molecules of the immune system. Together they offer a comprehensive objective evaluation of vaccine candidates selection in silico for fungal pathogens.

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Chaudhuri, R., & Ramachandran, S. (2017). Immunoinformatics as a tool for new antifungal vaccines. In Methods in Molecular Biology (Vol. 1625, pp. 31–43). Humana Press Inc. https://doi.org/10.1007/978-1-4939-7104-6_3

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