Cell Micropatterning: Self‐Organization of Fibroblast‐Laden 3D Collagen Microstructures from Inkjet‐Printed Cell Patterns (Adv. Biosys. 5/2020)

Abstract

In article number 1900280, Hwa-Rim Lee, Sungjune Jung, Ju An Park, and Seung-Yeol Park fabricate 3D collagen microstructures by 2D inkjet-printing of living cells in predestined designs. The patterns of fibroblasts printed on a collagen bed with controlled population density induce cell-to-extracellular matrix interaction between the cells and the surrounding collagen, which leads to self-organization of the 3D microstructures. This method provides a simple and powerful way to recapitulate the fine shape and microstructures of native tissues in 3D.