Stathmin is expressed by the proliferating hepatocytes during liver regeneration

15Citations
Citations of this article
7Readers
Mendeley users who have this article in their library.

Abstract

Aim - To determine the liver cell populations that express the phylogenetically conserved cytosolic protein stathmin during Liver regeneration. Methods - Double immunostaining for stathmin and the Ki67 antigen was performed on sections of formaldehyde fixed,. paraffin wax embedded tissues from 31 liver specimens. These included a variety of disease conditions characterised by some degree of hepatocyte regeneration. Quantitative western blot analysis was performed on 22 of these specimens. Results - Variable amounts of stathmin protein were detected by western blotting in all of the specimens examined. Stathmin was not detected in three cases of histologically normal liver. On immunostaining, stathmin was demonstrated in a proportion of hepatocytes as well as lymphoid inflammatory cells and other tissue elements. In all cases most of these stathmin positive cells showed nuclear positivity for the Ki67 antigen; Conclusions - Stathmin is expressed by proliferating hepatocytes but not by resting hepatocytes. Thus, it is likely that the protein has a function important to cell proliferation as opposed to cell differentiation.

Cite

CITATION STYLE

APA

Rowlands, D. C., Harrison, R. F., Jones, N. A., Williams, A., Hubscher, S. G., & Brown, G. (1995). Stathmin is expressed by the proliferating hepatocytes during liver regeneration. Journal of Clinical Pathology - Clinical Molecular Pathology, 48(2). https://doi.org/10.1136/mp.48.2.m88

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free