A persistent hotspot of schistosoma mansoni infection in a five-year randomized trial of praziquantel preventative chemotherapy strategies

Abstract

Background. Persistent hotspots have been described afer mass drug administration (MDA) for the control of schistosomiasis, but they have not been studied during the course of a multiyear MDA program. Methods. In data from a 5-year study of school-based and village-wide preventive chemotherapy strategies for Schistosoma mansoni, spatial scan staThistics were used to fnd infection hotspots in 3 populations: 5-to 8-year-olds, 9-to 12-year-olds, and adults. Negative binomial regression was used to analyze changes from baseline, and receiver operating characteristic analyses were used to predict which villages would reach prevalence and intensity endpoints. Results. We identifed a persistent hotspot, not associated with study arm, where S. mansoni infection prevalence and intensity did not decrease as much as in villages outside the hotspot. Signifcant di?erences from baseline were realized afer 1 year of MDA: we did not identify factors that moderated this relationship. Villages meeting specifed endpoints at year 5 were predicted from prior year data with moderately high sensitivity and specifcity. Conclusions. Te MDA strategies were less e?ective at reducing prevalence and intensity in the hotspot compared with other villages. Villages that reached year 5 endpoints could be detected earlier, which may provide the opportunity to amend intervention strategies.