Nickel, Cobalt and Palladium Catalysed C−H Functionalization of Un-Activated C(sp3)−H Bond

Abstract

This review represents nickel, cobalt and palladium catalyzed C−H activation of sp3 carbon, with special emphasis on methyl C−H activation. The importance of directing group assistance and effect of ligand on β- or γ- C(sp3)−H activation is summarized in this review. The mechanistic study for Ni, Co and Pd catalyzed sp3 C−H bond functionalization also discussed in detail.