A Caputo–Fabrizio fractional differential equation model for HIV/AIDS with treatment compartment

Abstract

In recent years, many new definitions of fractional derivatives have been proposed and used to develop mathematical models for a wide variety of real-world systems containing memory, history, or nonlocal effects. The main purpose of the present paper is to develop and analyze a Caputo–Fabrizio fractional derivative model for the HIV/AIDS epidemic which includes an antiretroviral treatment compartment. The existence and uniqueness of the system of solutions of the model are established using a fixed-point theorem and an iterative method. The model is shown to have a disease-free and an endemic equilibrium point. Conditions are derived for the existence of the endemic equilibrium point and for the local asymptotic stability of the disease-free equilibrium point. The results confirm that the disease-free equilibrium point becomes increasingly stable as the fractional order is reduced. Numerical simulations are carried out using a three-step Adams–Bashforth predictor method for a range of fractional orders to illustrate the effects of varying the fractional order and to support the theoretical results.