Polyglycine Modified Glassy Carbon Electrode for Ibuprofen Determination

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Abstract

A simple modification of bare glassy carbon electrode by electropolymerization of glycine by cyclic voltammetry was applied to the detection of ibuprofen. The polyglycine modified glassy carbon electrode was characterized by cyclic voltammetry and the electroactive surface area was determined. The study of ibuprofen in acetic acid buffer (0.25 M, pH 4.0) presented an electrocatalytic effect toward ibuprofen oxidation, increasing the current response and decrease of oxidation potential, at the modified electrode compared to the bare. Under the optimal conditions, the modified electrode gave a linear response in the ibuprofen concentration range of 10 to 200 μM, obtained correlation coefficient was 0.9993. the calculated limit of detection (3Sb/m) was 1.0 μM and the limit of quantification (10Sb/m) was 3.5 μM. the sensor was successfully used for the determination of ibuprofen in pharmaceutical preparations with satisfactory recoveries, 93–107 %. The new sensor showed good selectivity, repeatability, and reproducibility with satisfactory stability.

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Matijašević, I., Kulizić, M., Bacetić, L., Gavrilović, D., Baošić, R., & Lolić, A. (2023). Polyglycine Modified Glassy Carbon Electrode for Ibuprofen Determination. ChemistrySelect, 8(24). https://doi.org/10.1002/slct.202300827

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