Spectrophotometric determination of Chlorpromazine Hydrochloride by oxidative coupling reaction with P-Bromo aniline using Ammonium Ceric Sulphate Dihydrate

Abstract

A new sensitive spectrophotometric method for the determination of chlorpromazine hydrochloride (CPZH) was developed. The method is based on an oxidative coupling reaction with p-bromoaniline using ammonium ceric sulphate dihydrate as oxidizing agent to produce a violet color, soluble in water, stable product and absorbs at 553 nm. Beer's law was in the linear range 2.5-30 μg/ml of CPZH, the molar absorptivity, Sandellʼs sensitivity index and detection limit were 6.5731 × 10 3 liter. mol-1 .cm-1 , 0.0541 μg.cm-2 and 0.1361 μg/ml respectively. The RSD value was 1.20-1.36 % depending on the concentration. This method was applied successfully to the determination of chlorpromazine hydrochloride in two pharmaceutical formulations (tablets and injection).