Synthesis and biological activity of some novel N-dichloroacetyl-2,3- dihydrobenzoxazole derivatives

Abstract

A facile synthetic route was developed to N-dichloroacetyl-2,3- dihydrobenzoxazole derivatives 3 by cycloaddition of 2-amino-phenol (1) with dichloromethane and acylation of the resultant intermediate 2,3- dihydrobenzoxazole 2 with dichloroacetyl chloride. The structures of the compounds were characterized by IR, 1H NMR, and 13C NMR spectroscopy and elemental analysis. The preliminary biological tests showed that products 3 could protect maize against injury caused by acetochlor to some extent. Copyright © by Walter de Gruyter Berlin Boston.