Synthesis and Antibacterial activities of some Arabinofuranose-Schiff bases Derivatives

Abstract

As a continuous research for the discovery of new antibacterial agents due to the developing resistance toward conventional antibiotics, we reported a convenient synthetic approach for the preparation of methyl-α-D-arabinofuranoside shiff-bases. A series of arabinose-Shiff bases were prepared through the trityl protection of the primary hydroxyl group of methyl-α-D-arabinofuranoside, benzoylation, the removal of the trityl protective group, tosylation, azidation, conversion to the amine in the presence of triphenylphosphine, condensing reaction with a variety of aromatic aldehydes, and subsequent debenzoylation. New compounds were characterized by 1 H NMR and FTIR spectroscopy. Synthesised compounds were screened for antibacterial activity against several bacterial strains namely, Escherichia coli; Staphylococcus aureus; Bacillus subtilis; Candida albicans; Aspergillus niger, and they showed enhanced antibacterial activity.