Wound healing activity of alcoholic extract of solanum erianthum D.Don in excision and incision method

Abstract

Solanum erianthum D. Don is an unarmed shrub or small tree with dense indumentums of soft stellate hairs. Leaves are simple, ovate-elliptical; margin entire or slight wavy, base rounded to cuneate, and apex acute to acuminate. The leaves have been extensively used for leucorrhoea, piles, hemorrhoids, scrofula, headache, vertigo, digestive troubles and for wound healing purposes. Wistar albino rats of either sex weighing between 200 and 220g were topically treated with extract formulated in gel (10% and 20%) which was applied once daily in excision and incision wound model. Rats of standard groups were treated with 5% w/w Povidone-Iodine ointment topically. The percentage of wound contraction was increased, epithelization period was decreased and wound breaking strength was increased with topical application of AESE (Alcoholic Extract of Solanum erianthum) gel in excision and incision wound model. The experimental data revealed that the AESE displayed remarkable wound healing activity thus supports its traditional use. © 2010 IJRAP.