Enantioselective synthesis of substituted pyrrolidines by dynamic resolution

Abstract

Not restricted to allylic or benzylic derivatives: The dynamic resolution of chiral organolithium species in the presence of a chiral ligand, L*, followed by addition of an electrophile, E+ (see scheme), has been shown to occur with excellent enantioselectivity at ambient temperature by using nonactivated 2-lithiopyrrolidines.