Autophagy regulates inflammation following oxidative injury in diabetes

Abstract

ATG, autophagy-related; Atg7f/f:RIP-Cre, β-cell-specific Atg7-deficient; AGTR2, angiotensin II receptor, type 2; ATMs, adipose tissue macrophages; BECN1, Beclin 1, autophagy-related; CRP, C-reactive protein; ER, endoplasmic reticulum; IL18, interleukin 18; IL6, interleukin 6; IRF1, interferon regulatory factor 1; IAPP, islet amyloid polypeptide; IFNG, interferon, gamma; IRS1, insulin receptor substrate 1; IRS2, insulin receptor substrate 2; LAMP2, lysosome-associated membrane protein 2; LAMP2, lysosome-associated membrane protein 2; LC3, microtubule-associated protein 1 light chain 3; MAPK8, mitogen-activated protein kinase 8; MTOR, mechanistic target of rapamycin; NFKB, nuclear factor of kappa light polypeptide gene enhancer in B-cells; PI3K, phosphoinositide 3-kinase; PDX1, pancreatic and duodenal homeobox 1; TXNIP, thioredox ininteracting protein; 3-MA, 3-methyladenine. © 2013 Landes Bioscience.