Distinct anti-tumoral functions of adaptive immune cells in liver cancer

Abstract

hepatocellular carcinoma (hCC) commonly arises in chronically infamed livers, but may also provoke (anti-tumoral) immune responses. using non-infammatory diethylnitrosamine (DeN)-induced liver cancer in mice, we demonstrate that distinct axes of the adaptive immune system, which are also prognostic in human hCC, actively suppress hepatocarcinogenesis by controlling tumor formation and progression.©2012 Landes Bioscience.