Irreversible end-stage heart failure in a young patient due to severe chronic hypocalcemia associated with primary hypoparathyroidism and celiac disease

Abstract

Background: Chronichypocalcemiamay cause electrocardiographic (ECG) changes andmimic acutemyocardial infarction. It has also been associatedwith reversible cardiac dysfunction.On the other hand cardiomyopathy and heart failure have been reported in patientswith idiopathic hypoparathyroidism or celiac disease. Clinical Case: A 39-year-old male was admitted to the emergency room with acute retrosternal pain and dyspnea. He exhibited severe hypocalcemia and acute renal failure. High creatine kinase (CK) levels did not correlate with biomarkers of myocardial necrosis (negativetroponin test, heart type creatine kinase isoenzyme (CK-MB) <1% of CK value). The ECG showed an extremely long QT interval (0.6 sec) and T-wave inversions on V4 through V6. The left ventricular ejection fraction (LVEF) was as low as 25%, while coronary angiography was normal. Investigation of the hypocalcemia revealed primary hypoparathyroidism (Parathyroid hormone (PTH) <3 pg/ml) and concomitant celiac disease with positive antigliadin and endomysial antibodies. The cardiovascular episodes and the dilated heart failure were attributed to the chronic hypocalcemia since no other cause was found. The correction of hypocalcemia has not been sufficient to reverse the end-stage heart failure after more than 6 months of treatment, even though ECG abnormalities have receded, implying permanent cardiac impairment. Conclusion: This case demonstrates an unusual clinical condition where 2 calcium homeostasis disorders led to severe hypocalcemia with clinical manifestations of end-stage heart failure. The severe cardiac failure appeared to be nonreversible after calcium repletion suggesting permanent cardiac muscle dysfunction due to associated cardiomyopathy. © 2010 Wiley Periodicals, Inc.