Antifouling potentials and metabolite profiles of two marine-derived fungal isolates

Abstract

Extracts of the culture broths of Aspergillus sydowii SCSIO 00305 and Penicillium chrysogenum SCSIO 00258 exhibited a relatively broad spectrum of antifouling activity against various biofoulers. The main chemical components of their bioactive fractions were analyzed and identified by LC-MS and from literature data. Two bioactive fractions comprised of 1α-methoxyroquefortine C, meleagrin, roquefortine C and isoroquefortine C exhibited more significant anti-barnacle activity than meleagrin in field bioassays, suggesting that the combination of different bioactive compounds could display a stronger antifouling activity than a single compound in the complicated marine ecological environments.