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Studies on the biosynthesis of epothilones: The PKS and epothilone C/D monooxygenase

Journal of Antibiotics (2001) 54(2) 144-148
DOI: 10.7164/antibiotics.54.144
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Abstract

Nonproducer mutants support the assumption that epothilones A and B are synthesized by the same polyketide synthase (PKS). The endproducts of the PKS, epothilones C and D, compete for the active site of a constitutively synthesized monooxygenase which is regulated by product inhibition. The postulated C-13 hydroxy-epothilones as direct precursors of epothilones C and D were not detected.

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APA

Gerth, K., Steinmetz, H., Höfle, G., & Reichenback, H. (2001). Studies on the biosynthesis of epothilones: The PKS and epothilone C/D monooxygenase. Journal of Antibiotics, 54(2), 144–148. https://doi.org/10.7164/antibiotics.54.144

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