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CircR-looping the leukemic translocations: The cause of MLL translocations explained

Molecular Cell
DOI: 10.1016/j.molcel.2023.05.037
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Abstract

Conn et al.1 identify circular RNAs (circRNAs) derived from mixed lineage leukemia (MLL) breakpoint cluster regions, demonstrating a causal role of circRNAs in MLL translocations. CircRNAs:DNA hybrids (circR-loops) trigger RNA polymerase pausing, driving oncogenic gene fusions via endogenous RNA-directed DNA damage.

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APA

Chen, M. (2023, July 6). CircR-looping the leukemic translocations: The cause of MLL translocations explained. Molecular Cell. Cell Press. https://doi.org/10.1016/j.molcel.2023.05.037

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