Olfactory neuroblastoma: Past, present, and future?

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Abstract

Objective: To consider the long-term survival and outcomes in patients with olfactory neuroblastoma undergoing craniofacial resection. Study Design: A single-center prospective cohort study. Methods: All patients with olfactory neuroblastoma treated in a 23-year period with craniofacial resection (with or without radiotherapy) were analyzed; a multivariate analysis was included. Results: Forty-two patients aged 12 to 70 years were assessed, 83% of whom had received no preceding treatment. Craniofacial resection was used in all cases, combined with radiotherapy in 24 patients (57%). Duration of follow-up ranged from 2 to 206 months (mean follow-up period, 57 mo). The disease-free actuarial survival and overall survival were 77% and 61% at 5 years and 53% and 42% at 10 years, respectively. A Cox regression analysis identified intracranial extension and orbital involvement as independent factors affecting outcome. Conclusion: Craniofacial resection combined with radiotherapy offers the gold standard of care against which other approaches such as endoscopic resection must be judged.

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Lund, V. J., Howard, D., Wei, W., & Spittle, M. (2003). Olfactory neuroblastoma: Past, present, and future? Laryngoscope, 113(3), 502–507. https://doi.org/10.1097/00005537-200303000-00020

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