Serologic evidence of powassan virus infection in patients with suspected lyme disease

Abstract

Powassan virus (POWV) lineage II is an emerging tick-borne flavivirus with an unknown seroprevalence in humans. In a Lyme disease–endemic area, we examined the seroreactivity to POWV in 2 patient cohorts and described the clinical features of the POWV-seroreactive patients. POWV disease might be less neuroinvasive than previously thought.